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. 2016 Oct 24;38(1):69–79. doi: 10.1038/aps.2016.119

Figure 6.

Figure 6

In vitro evidence of FXR activation by AB23A. (A) AB23A induced Apo C-II in mouse primary cultured hepatocytes in a dose-dependent manner. Quantitative real-time PCR analysis was performed to measure gene expression and data are expressed as the mean±SD. n=5/group. *P<0.05 vs DMSO vehicle. (B) FXR silencing efficiency was measured by Western blotting. (C) FXR silencing abrogated the regulation of Apo C-II, CPT1α, ACADS and LPL by AB23A in mouse primary hepatocytes. Data are expressed as the mean±SD. n=5. *P<0.05 vs DMSO alone. #P<0.05 vs AB23A alone.