Table 3.
Comparison of CFD Predictions of Deposition Fraction (DF)a as a Percentage of aerosolized Dose to the In Vivo Data of Newman et al.(62) Normalized for the Aerosolized Dose from the Novolizer Inhaler Operated with the PIFR = 65 LPM Inhalation Waveform and PSD Based on Particle Sizing Flow Rate of 60 LPM (Model C Upper Airway Geometry)
| PIFR (LPM) | 65 |
| Inlet MMAD (μm) | 2.4 |
| Particle sizing flow rate (LPM) | 60 |
| MT | 75.8 (71.0) |
| Central lung with trachea excluded | 8.3 (9.0) |
| Intermediate and peripheral lung | 15.9 (19.8) |
| Trachea–B3 | 6.6 |
| B4–B7 | 4.4 |
| B8–B15 | 1.9 |
| Alveolar | 14.0 |
a
The in vivo data is shown in parentheses. Comparisons with the in vivo data are based on 2D planar projections of the CFD predictions. Deposition fractions based on the typical SIP approach for subdividing the lungs are also provided.