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Contribution of CC’ loop in the recognition of TIGIT:TIGIT/nectin-2/PVR. (A) Structure-based sequence alignment study shows the insertion of two and five residues at the CC’ loop of PVR and nectin-2 respectively, in comparison to the CC’ loop of TIGIT. (B) The CC’ loop of PVR contributes to the heterophilic interaction. In particular, 72SGS74 from the CC’ loop of PVR makes several contacts with G strand residues (115DGT117) of the engaging TIGIT.
