Table 1.
Minimal inhibitory concentrations (MICs) of HDPs from arachnids.
| Microorganisms | MIC (μM) |
|
|---|---|---|
| Rondonin (35) | Oligoventin | |
| Gram-positive bacteria | ||
| Micrococcus luteus A270 | ND | 47.2–94.5 |
| Staphylococcus aureus ATCC 29213 | ND | 94.5–188.9 |
| Staphylococcus epidermidis ATCC 12228 | ND | 94.5–188.9 |
| Gram-negative bacteria | ||
| Escherichia coli SBS363 | NT | ND |
| Escherichia coli ATCC 25922 | NT | ND |
| Pseudomonas aeruginosa ATCC 27853 | NT | ND |
| Serratia marcescens ATCC 4112 | NT | 23.53–47.2 |
| Fungi | ||
| Trichosporon sp. IOC 4569 | 1.1–2.1 | ND |
| Yeasts | ||
| Candida albicans MDM8 | 16.75–33.5 | 94.5–188.9 |
| Candida krusei IOC 4559 | 16.75–33.5 | ND |
| Candida glabrata IOC 4565 | 8.37–16.5 | ND |
| Candida albicans IOC 4558 | 8.37–16.5 | ND |
| Candida parapsilosis IOC 4564 | 16.75–33.5 | ND |
| Candida tropicalis IOC 4560 | 8.37–16.5 | ND |
| Candida guilliermondii IOC 4557 | 16.75–33.5 | ND |
The highest concentration tested was 189 µM. ND, activity was not detected in the range of concentrations tested. NT, antimicrobial activity was not tested or previously not reported (35). Rondonin is an hemocyanin-encrypted antifungal HDP from the tarantula Acanthoscurria rondoniae (19, 35).
MICs are expressed as the interval of two concentrations, where the first is the highest concentration tested at which microorganisms from each strain grew and the second is the lowest concentration tested that caused 100% growth inhibition (33–35, 38, 39).