Table 1.

Studies testing the association between DHEA(S) and mortality

Author, Year, Ref	Time of follow up (years)	Number and age of Subjects	Results
PROS*
Barrett-Connor (1986) ref 16	12 years	242 men 50–79 years	Low DHEAS is a predictor of death It is inversely related with all-cause mortality (36%) and with cardiovascular mortality (48%)
Cappola (2006) ref 19	8 years	952 subjects of both sexes (Cardiovascular Health Study) age >65 yr (median ♂ 72.5 yr, median ♀ 73.2 yr)	DHEA is predictor of mortality in women with significant decline in DHEA levels DHEA is predictor of mortality in men with significant decline in DHEA levels
CONS**
Tilvis (1999) ref 20	5 years	571 subjects 75 years and older	DHEAS is not predictor of 5 yr mortality, but subjects who died had lower DHEA levels
Mazat (2001) ref 17	8 years	290 subjects (119 ♂, 171 ♀) 65 years older	DHEAS is not predictor of 8 –yr mortality in women. DHEA is predictor of mortality only in smokers subjects and 65–69 yr old men.
Cappola (2009) ref 18	5 years	539 women WHAS I Study age 65–101 yr (median 77.6 yr)	DHEAS is predictor of cardiovascular mortality in women with lower DHEAS levels. DHEAS is predictor of cancer mortality in women with higher DHEAS levels
Maggio (2007) ref 28	6 years	410 men (InCHIANTI Study) age > 65 yr	DHEAS, Testosterone, IGF-I (in the lowest quartiles of the population), were an independent predictor of all cause mortality. On the contrary, serum levels of each of these hormones considered separately were not associated with mortality

^*PROS: supporting the hypothesis that single hormonal derangement is predictor of mortality

^**CONS: against this hypothesis