Table 2.
Studies testing the association between testosterone and mortality
| Author Year Ref | Time of follow up (years) | Number and age of Subjects | Results |
|---|---|---|---|
| PROS | |||
| Shores MM (2006) ref 22 |
4.3 | 858 aged 3 40 yr |
Low testosterone levels are associated with an increased mortality risk either in an unadjusted model or in partially and fully adjusted model |
| Knaw KT (2007) ref 23 |
7 | 11606 40–79 yr |
Lowest quartile of TT levels are inversely related to mortality due to all-causes, cardiovascular and cancer causes, but not in chronic heart disease mortality |
| Laughlin GA (2008) ref 24 |
11.8 | 794 50–91 yr (median 73,6) |
Lowest quartile of TT and BioT levels are inversely related to mortality due to all-causes, cardiovascular and respiratory causes, but are not significantly related with cancer cause |
| Menke A (2010) ref 25 |
9 yr | 1114 men age 3 20 yr |
Men with low free and bioavailable testosterone levels may have a higher risk of mortality within 9 years of hormone measurement |
| CONS | |||
| Smith GD (2005) ref 26 |
16.5 | 2512 45–59 yr |
Positive Association between Cortisol/Testosterone Ratio and ischemic heart disease mortality, but no association between testosterone and CV death, incident ischemic heart disease |
| Araujo AB 2007) ref 27 |
15.3 | 1686 40–70 yr |
In multivariate-adjusted models higher FT and lower DHT levels are associated with ischemic heart disease. Moreover higher FT levels are associated with respiratory mortality, but TT e SHBG level not associated with all-cause mortality |
| Maggio M (2007) ref 28 |
6 | 410 aged 3 65 yr |
Low circulating levels of multiple anabolic hormones, including BioT, IGF-I and DHEAS (in the lowest quartiles), are independent predictor of mortality |