Figure 2.

Therapeutic effect of adipose tissue-derived mesenchymal stem cells (AT-MSCs). A — Lameness was rated by the owners using a questionnaire modified from Black et al (15). Results were substantiated by the nonparametric Wilcoxon test. *P < 0.001, N = 39. B — Images were excised from videos taken during arthroscopic surgery 3 wk before MSC injection (left image) and control arthroscopy 1 y after transplantation (right image). Images represent the same area of the joint. C — Images of tissue samples at 200× magnification, stained with hematoxylin and eosin (H&E, upper row) and Safranin O (lower row), obtained from the regenerated cartilage (left column), a healthy meniscus cartilage (middle), and healthy cartilage (right column). Scale bar = 50 μm.