Table 3.

Relationship between clinicopathological characteristics and PIK3CA mutation status

Characteristics	PIK3CA mutation status				P value
	Wild-type		Mutant
	Number	%	Number	%
Mean age ± SD	62.8 ± 7.1		61.9 ± 5.6		0.643
Gender					0.469
Male	140	83.3	10	76.9
Female	28	16.7	3	23.1
Smoking status					0.468
Non-smoker	32	19.0	1	7.7
Smoker	136	81.0	12	92.3
Alcohol consumption					1.000
Non-drinker	14	8.3	1	7.7
Drinker	154	91.7	12	92.3
Location					1.000
Upper/Middle	101	60.1	8	61.5
Lower	67	39.9	5	38.5
T factor					0.247
1–2	70	41.7	3	23.1
3–4	98	58.3	10	76.9
Lymph node metastases					1.000
Absent	52	31.0	4	30.8
Present	116	69.0	9	69.2
TNM stage					0.775
I-II	76	45.2	5	38.5
III-IV	92	54.8	8	61.5
Histological differentiation					1.000
W/D, M/D	146	86.9	12	92.3
P/D	22	13.1	1	7.7
Lymphatic invasion					0.400
Absent	81	48.2	8	61.5
Present	87	51.8	5	38.5
Venous invasion					0.470
Absent	35	20.8	1	7.7
Present	133	79.2	12	92.3

Abbreviations: SD standard deviation, W/D well differentiated, M/D moderately differentiated, P/D poorly differentiated