Fig. 4.

Heatmap of plasma proteins significantly associated with free thyroxine (FT₄) in mixed effect linear regression models. The first column displays the values of the mean false discovery rate (FDR) for the FT₄ effect across 101 subsamples of the data coded in grey color. The other columns indicate the mean log₂-ratio from baseline (bas) compared to 4 (w4(T4)) and 8 (w8(T4)) weeks of treatment as well as 4 (w12) and 8 (w16) weeks after finishing the treatment. The time course of FT₄ concentrations is shown on the top of the map as reference. Orange shading denotes an increase and blue shading a decrease compared to baseline, respectively. Derived physiological signatures are labeled on the left. The corresponding estimates and FDR values from regression analysis can be found in Additional file 2: Table S2