Table 2.
Cardiovascular measures at study entry
| Measurements and Classifications | Stage 3a | Stage 3b | Stage 4 | Stage 5 | All |
|---|---|---|---|---|---|
| Systolic office BP | |||||
| Millimeters of mercury | 112 (15) | 114 (15) | 111 (15) | 117 (15) | 112 (15) |
| SDS | 0.60 (1.16) | 0.92 (1.39) | 0.67 (1.34) | 1.27 (1.39) | 0.79 (1.36) |
| Diastolic office BP | |||||
| Millimeters of mercury | 70 (11) | 70 (13) | 68 (12) | 74 (12) | 69 (12) |
| SDS | 0.67 (0.94) | 0.71 (1.12) | 0.59 (1.07) | 1.10 (1.08) | 0.67 (1.09) |
| 24-h Mean arterial pressure | |||||
| Millimeters of mercury | 88.2 (8.8) | 85.0 (9.5) | 85.0 (10.3) | 90.1 (12.0) | 85.6 (10.1) |
| SDS | 1.16 (1.61) | 0.71 (1.65) | 0.74 (1.73) | 1.59 (2.03) | 0.82 (1.73) |
| Confirmed normotension, N (%) | 25 (61.0) | 114 (63.3) | 189 (66.3) | 13 (34.2) | 341 (62.7) |
| White coat hypertension, N (%) | 6 (14.6) | 22 (12.2) | 26 (9.1) | 7 (18.4) | 61 (11.2) |
| Masked hypertension, N (%) | 7 (17.1) | 21 (11.7) | 43 (15.1) | 8 (21.1) | 79 (14.5) |
| Confirmed hypertension, N (%) | 3 (7.3) | 23 (12.8) | 27 (9.5) | 10 (26.3) | 63 (11.6) |
| No. of antihypertensive drugs | 1.2 (1.3) | 1.3 (1.1) | 1.6 (1.3) | 1.6 (1.5) | 1.4 (1.3) |
| Normotension without treatment, N (%) | 13 (31.7) | 35 (19.4) | 58 (20.4) | 6 (15.8) | 112 (20.6) |
| Controlled hypertension, N (%) | 18 (43.9) | 101 (56.1) | 157 (55.1) | 14 (36.8) | 290 (53.3) |
| Uncontrolled hypertension, N (%) | 10 (24.4) | 44 (24.4) | 70 (24.8) | 18 (47.4) | 142 (26.1) |
| LV mass index, g/m2.7 | 30.6 (8.1) | 35.3 (12.0) | 37.9 (11.5) | 40.8 (16.6) | 36.8 (12.1) |
| LV hypertrophy, N (%) | 5 (10.6) | 56 (28.1) | 126 (37.5) | 24 (48.0) | 211 (33.4) |
| Eccentric | 0 (0.0) | 19 (9.5) | 49 (14.6) | 7 (14.0) | 75 (11.9) |
| Concentric | 5 (10.6) | 37 (18.6) | 77 (22.9) | 17 (34.0) | 136 (21.5) |
| Concentric LV remodeling, N (%) | 18 (38.3) | 61 (30.7) | 74 (22.0) | 11 (22.0) | 164 (25.9) |
| Carotid intima-media thickness | |||||
| Millimeters | 0.46 (0.06) | 0.44 (0.06) | 0.45 (0.06) | 0.46 (0.07) | 0.45 (0.06) |
| SDS | 1.81 (1.36) | 1.39 (1.36) | 1.66 (1.46) | 1.87 (1.77) | 1.60 (1.45) |
| Elevated carotid intima-media thickness, N (%) | 20 (40.8) | 73 (34.0) | 162 (46.0) | 22 (44.0) | 277 (41.6%) |
| Pulse wave velocity | |||||
| Meters per second | 5.12 (1.01) | 4.91 (0.79) | 4.85 (0.82) | 5.07 (0.88) | 4.90 (0.83) |
| SDS | 0.37 (1.50) | 0.23 (1.51) | 0.31 (1.77) | 0.79 (1.67) | 0.33 (1.66) |
| Elevated pulse wave velocity, N (%) | 9 (19.1) | 37 (17.3) | 76 (21.5) | 10 (20.4) | 133 (20.1) |
Values are presented as mean (SD) unless otherwise indicated. Ambulatory BP monitoring–derived data are on the basis of 545 patients. SDS, SD score; LV, left ventricular.