Table 3.
Linear regression models of variables associated with surrogate markers at study entry after stepwise variable selection
| Variable | LVMI, n=493 | cIMT SDS, n=510 | PWV SDS, n=513 | |||
|---|---|---|---|---|---|---|
| β (95% CI) | P Value | β (95% CI) | P Value | β (95% CI) | P Value | |
| Intercept | 70.7 (61.3 to 80.1) | <0.001 | 0.58 (0.01 to 1.15) | 0.05 | 0.2 (−0.5 to 0.9) | 0.56 |
| Age, yr | −0.715 (−1.0 to −0.41) | 0.001 | — | −0.06 (−0.10 to −0.02) | 0.01 | |
| Girls | −2.54 (−4.58 to −0.49) | 0.02 | 0.31 (0.05 to 0.57) | 0.02 | — | |
| Systolic BP (SDS) | 1.15 (0.43 to 1.88) | <0.001 | 0.22 (0.13 to 0.31) | <0.001 | 0.37 (0.26 to 0.48) | <0.001 |
| Physical activity >2 h/wk | −3.94 (−5.95 to −1.93) | 0.001 | 0.25 (0.00 to 0.5) | 0.04 | ||
| BMI SDS | 1.43 (0.68 to 2.17) | 0.001 | 0.08 (−0.13 to 0.17) | 0.09 | — | |
| HDL cholesterol, mg/dl | −0.09 (−0.16 to −0.02) | 0.001 | — | — | ||
| LDL cholesterol, mg/dl | −0.03 (−0.06 to 0.00) | 0.02 | ||||
| Serum 25-OHD, ng/ml | — | −0.01 (−0.02 to 0.00) | 0.004 | −0.01 (−0.24 to 0.00) | 0.01 | |
| eGFR, ml/min per 1.73 m2 | −0.22 (−0.32 to −0.13) | <0.001 | — | — | ||
| Serum albumin, g/L | −0.20 (−0.37 to −0.04) | 0.07 | — | — | ||
| Log urine albumin-to-creatinine ratio | 0.10 (0.02 to 0.18) | 0.01 | ||||
| Serum phosphorus, mmol/L | — | 0.72 (0.4 to 1.0) | <0.001 | |||
| iPTH, ng/ml | — | — | 0.01 (0.00 to 0.01) | 0.002 | ||
Supplemental Table 5 shows full models. LVMI, left ventricular mass index; cIMT, carotid intima-media thickness; SDS, SD score; PWV, pulse wave velocity; 95% CI, 95% confidence interval; —, no significant correlation for this variable; BMI, body mass index; 25-OHD, 25-hydroxy vitamin D; iPTH, immunoreactive parathyroid hormone.