Table 2.
Association of urinary uromodulin-to-creatinine ratio and postoperative AKI
| Urinary Uromodulin-to-Creatinine Ratio | No. of Events (%) | Unadjusted OR (95% CI) | Model 1 OR (95% CI) | Model 2 OR (95% CI) |
|---|---|---|---|---|
| AKI | ||||
| Per 1 SDa ↓ | 64 (29.4) | 1.49 (1.04 to 2.13), P=0.03 | 1.53 (1.06 to 2.20), P=0.02 | 1.43 (0.99 to 2.07), P=0.06 |
| Quartile 1 (0.8–4.1), μg/g | 20 (37.0) | 2.94 (1.19 to 7.26) | 2.98 (1.19 to 7.46) | 2.43 (0.91 to 6.48) |
| Quartile 2 (4.2–9.9), μg/g | 18 (32.7) | 2.43 (0.98 to 6.05) | 2.70 (1.06 to 6.86) | 2.21 (0.81 to 6.01) |
| Quartile 3 (10.0–22.8), μg/g | 17 (30.9) | 2.24 (0.89 to 5.59) | 2.10 (0.84 to 5.26) | 1.69 (0.64 to 4.48) |
| Quartile 4 (22.9–93.7), μg/g | 9 (16.7) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Trend P value | 0.02 | 0.02 | 0.06 | |
| Severe AKI | ||||
| Per 1 SDa ↓ | 8 (3.7) | 3.15 (0.71 to 13.96), P=0.13 | 2.68 (0.85 to 8.42), P=0.09 | 2.03 (0.80 to 5.17), P=0.14 |
| Below versus above medianb | 7 (87.5) | 7.41 (0.90 to 61.3), P=0.06 | 6.67 (1.22 to 36.30), P=0.03 | 4.03 (0.87 to 18.70), P=0.08 |
Model 1: adjusted for age, sex, and race. Model 2: model 1 plus eGFR, diabetes, heart failure, left ventricular ejection fraction, elective versus nonelective surgery, valvular versus other cardiac surgery, and urine albumin-to-creatinine ratio. OR, odds ratio; 95% CI, 95% confidence interval.
a
1 SD=14.8 μg/g.
b
There was a total of eight events of severe AKI, of which seven (85%) occurred in the first two quartiles (below the median).