Table 3.
Association of urinary uromodulin-to-creatinine ratio with postoperative peak serum creatinine
Uromodulin-to-Creatinine Ratio | Mean (SD) Peak Creatinine | Difference in Mean Peak Serum Creatinine (95% CI) | Model 1 Difference in Mean Peak Serum Creatinine (95% CI) | Model 2 Difference in Mean Peak Serum Creatinine (95% CI) |
---|---|---|---|---|
Per 1 SDa ↓ | 1.3 (0.5) | 0.11 (0.04 to 0.18), P=0.002 | 0.10 (0.03 to 0.17), P=0.003 | 0.07 (0.02 to 0.13), P<0.01 |
Quartile 1 (0.8–4.1), μg/g | 1.4 (0.5) | 0.27 (0.08 to 0.47) | 0.23 (0.05 to 0.42) | 0.14 (−0.01 to 0.29) |
Quartile 2 (4.2–9.9), μg/g | 1.4 (0.7) | 0.35 (0.16 to 0.55) | 0.34 (0.16 to 0.53) | 0.23 (0.08 to 0.38) |
Quartile 3 (10.0–22.8), μg/g | 1.3 (0.5) | 0.21 (0.02 to 0.40) | 0.17 (−0.01 to 0.36) | 0.06 (−0.09 to 0.21) |
Quartile 4 (22.9–93.7), μg/g | 1.1 (0.3) | 0 | 0 | 0 |
Trend P value | 0.002 | <0.01 | 0.01 |
Model 1: adjusted for age, sex, and race. Model 2: model 1 plus eGFR, diabetes, heart failure, left ventricular ejection fraction, elective versus nonelective surgery, valvular versus other cardiac surgery, and urine albumin-to-creatinine ratio. 95% CI, 95% confidence interval.
1 SD=14.8 μg/g.