Table 4.
Associations of ejection fraction clinical cut points with incident heart failure and death in the Chronic Renal Insufficiency Cohort participants without baseline heart failure
| Ejection Fraction, % | N (Events) | N (Participants) | Rate | HR (95% CI) | ||
|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||
| Heart failure | ||||||
| >65 | 6 | 193 | 5.4 | 0.39 (0.17 to 0.89) | 0.41 (0.18 to 0.94) | 0.38 (0.16 to 0.94) |
| 50–65 | 177 | 2205 | 15.1 | Reference | Reference | Reference |
| 35–50 | 52 | 433 | 24.3 | 1.52 (1.09 to 2.13) | 1.59 (1.14 to 2.24) | 1.57 (1.12 to 2.21) |
| <35 | 13 | 48 | 66.5 | 5.02 (2.76 to 9.14) | 5.2 (2.78 to 9.72) | 3.67 (1.93 to 6.99) |
| Linear trend P value | <0.001 | <0.001 | <0.001 | |||
| Death | ||||||
| >65 | 18 | 193 | 14.4 | 0.7 (0.43 to 1.13) | 0.72 (0.45 to 1.17) | 0.63 (0.37 to 1.07) |
| 50–65 | 336 | 2205 | 24.0 | Reference | Reference | Reference |
| 35–50 | 73 | 433 | 26.9 | 1.02 (0.77 to 1.34) | 1.03 (0.78 to 1.36) | 0.94 (0.71 to 1.24) |
| <35 | 20 | 48 | 76.8 | 2.38 (1.48 to 3.84) | 2.49 (1.53 to 4.07) | 0.94 (0.71 to 1.24) |
| Linear trend P value | 0.004 | <0.01 | 0.04 | |||
Model 1: age, race, study site, diabetes, cardiovascular disease, tobacco, alcohol use, log(24-hour proteinuria), eGFR (Chronic Renal Insufficiency Cohort equation), systolic BP, diastolic BP, body mass index, LDL, HDL, aldosterone antagonists, angiotensin–converting enzyme inhibitors, angiotensin receptor blockers, diuretics, β-blockers, phosphate, and hemoglobin. Model 2: model 1 plus log(parathyroid hormone), log(fibroblast growth factor-23), aspirin, and statin. Model 3: model 2 plus log(B–type natriuretic peptide) and log(high–sensitivity troponin T). HR, hazard ratio; 95% CI, 95% confidence interval.