Table 2.
Histologic features in biopsies with SAGN (n=78)
| Biopsy Features | SAGN (n=78) | Primary IgAN (n=100) | SAGN versus IgAN P Value (Chi Square) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Endocarditis (n=18) | Bacteremia of Unknown Source (n=10) | Osteomyelitis, Septic Arthritis (n=17) | Infected Skin Ulcers (n=17) | Pneumonia (n=6) | Others (n=10) | Total, n (%) | |||
| Biopsies with endocapillary hypercellularity | 12 | 6 | 10 | 11 | 4 | 4 | 47 (60); (Diffuse in 26 of 47) | 10% | <0.001 |
| Biopsies with focal crescents/necrotizing lesions | 7 | 2 | 7 | 2 | 4 | 5 | 27 (35) | 20% | 0.03 |
| Biopsies with FSGS | 0 | 0 | 0 | 1 | 1 | 0 | 2 (2.5) | 49% | <0.001 |
| Biopsies with subepithelial humps | 4 | 3 | 4 | 7 | 2 | 4 | 24 (31) | 0% | <0.001 |
| Patients with diabetes mellitus, n (%) | 3 (17) | 2 (20) | 10 (59) | 13 (76) | 1 (17) | 3 (30) | 32 (41) | 8% | <0.001 |
| Biopsies with nodular diabetic glomerulosclerosis (nodular mesangial expansion) | 0 | 2 | 5 | 6 | 1 | 2 | 16 (21) | 1% | <0.001 |
Corresponding features in 100 biopsies of primary IgAN with P values are shown for comparison. Number of patients with diabetes mellitus and diabetic glomerulosclerosis are also shown. SAGN, Staphylococcus infection–associated GN; IgAN, IgA nephropathy.