Table 2.

Relationship between gene expression levels in carotid artery plaques of TLR7 and outcome

	Major adverse cardio- or cerebrovascular event		Ischaemic event
	Microarray (n=123)	qPCR (n=133)	Microarray (n=123)	qPCR (n=133)
TLR7, unadjusted	2.38 (P=0.012) CI 1.21–4.67	1.91 (P=0.027) CI 1.08–3.4	2.28 (P=0.044) CI 1.02–5.09	1.67 (P=0.145) CI 0.84–3.31
TLR7, adj. for age	2.2 (P=0.023) CI 1.12–4.34	1.91 (P=0.027) CI 1.08–3.39	2.10 (P=0.072) CI 0.936–4.69	1.63 (P=0.163) CI 0.82–3.24
TLR7, adj. for sex	2.33 (P=0.014) CI 1.18–4.59	1.87 (P=0.033) CI 1.05–3.32	2.24 (P=0.049) CI 1–5.02	1.63 (P=0.162) CI 0.82–3.25
TLR7, adj. for LDL	2.35 (P=0.014) CI 1.19–4.64	1.90 (P=0.028) CI 1.07–3.38	2.20 (P=0.057) CI 0.978–4.93	1.65 (P=0.155) CI 0.83–3.28
TLR7, adj. for age and sex	2.18 (P=0.024) CI 1.11–4.30	1.82 (P=0.042) CI 1.02–3.23	2.07 (P=0.076) CI 0.93–4.63	1.57 (P=0.199) CI 0.79–3.13
TLR7, adj. for age, sex and LDL	2.2 (P=0.024) CI 1.11–4.35	1.80 (P=0.045) CI 1.01–3.21	2.02 (P=0.090) CI 0.90–4.56	1.55 (P=0.214) CI 0.78–3.09

Hazard ratio (HR) (95% confidence interval, P-values) from Cox regression models for the lowest tertile of TLR7 expression vs. the middle and highest combined.