Table 2.

Cases of Q fever endocarditis reported in PUMCH from 2006 to 2016

Items	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6
Gender	Male	Male	Male	Male	Male	Male
Age (years)	41	22	61	54	55	58
NYHA classification	2	3	1	2	N/A	3
Symptoms	Fever, cough, jaundice	Fever, cough, chest pain	Fever, erythema	Fever, arterial embolism	Fever, weight loss, cough	Fever, chills, weakness, weight loss
Cardiac findings	Mitral aortic valve deformity, aortic valve vegetation	Vegetations on chordae tendineae of the anterior leaflet of the mitral valve	Aortic valve thickening with vegetations	Vegetations on bioprosthetic aortic valve, mild to moderate aortic perivalvular leakage	Stenosis and Regurgitation of aortic and mitral valves. Aortic valve vegetation	Atrial perivalvular abscess and vegetation. Mitral valve regurgitation
Phase I IgG	1:800	1:1600	1:>5120	1:3200	>1:1600	1:6400
Phase II IgG	1:800	1:800	1:>5120	1:800	>1:1600	N/A
Antimicrobial therapy	Minocycline	Doxycycline + SMZ–TMP	Doxycycline	Minocycline + HCQ	Amikacin + vancomycin	Minocycline + HCQ
Operation	No	No	No	Yes, due to congestive heart failure	Yes	No
Follow–up (months)	53	30	37	36	24	48
Outcome	Cure	Cure	Cure	Bioprostheticvalvuloplasty and cure	Cure	Stable*

*Reported to be stable upon discharge, further details unknown. NYHA: New York Heart Association; SMZ–TMP: Sulfamethoxazole–trimethoprim; HCQ: Hydroxycholoroquine; PUMCH: Peking Union Medical College Hospital; N/A: Not available.