Table 3.
Functional analysis of the predicted targets of miRNAs exhibiting >2-fold changes in response to both concentrations of EGCG
| miRNA name | Apoptosis | Cell cycle | Cell proliferation |
|---|---|---|---|
| hsa-miR-1202 | PAK2 | ARL3, PAFAH1B1, EML4, UHMK1, SMAD3 | ETS1, SMAD3 |
| hsa-miR-1207-5p | ARC, MKL1, IGF1, MCL1, UBE2Z, TNS4, SH3KBP1, CSRNP1, BCAP31, RTN3, SARM1, MCL1 | FOXO4, PPP1R9B, GAS7, APBB1, IGF1, RBM14, CAMK2A, FOXN3 | SRC, LRP1, ERF, ELN, ACVRL1, DRD2, PTPRU, FGF9, NACC1, GNAI2, IGF1, PPP1R9B, APBB1, FOXO4 |
| hsa-miR-1225-5p | – | SH3BP4 | – |
| hsa-miR-1246 | SEMA6A | CREBL2 | – |
| hsa-miR-1915 | PDE1B, ZC3H12A, E2F2, SHB, SMAD3 | SET, RAD9A, NF2, GAS7, SMAD3, E2F2 | SMAD3, SOCS7, NRAS |
| hsa-miR-1973 | – | RPRM | – |
| hsa-miR-210 | BDNF | – | – |
| hsa-miR-2861 | ALX4, BMF, SARM1, MKL1, PPP1R13B, E2F2, SGPL1 | PPP1R13B, FOXN3, PPP1CA | FURIN, VSX2 |
| hsa-miR-3162 | AKTIP | – | – |
| hsa-miR-3196 | PIK3R2 | – | – |
| hsa-miR-34a | MET, MDM4, SGPP1, HSPA1B, PEA15, SYVN1, SRC, NOTCH1, IL6R, ERC1 | MTUS1, SIPA1, CCNE2, STRN3, CDK6, MAPK13, PDGFRA, KITLG, MDM4 | NOTCH1, MARCKSL1, KITLG, PDGFRB, SIPA1, ADIPOR2, MAP2K1, CSF1R, CBFA2T3, UHRF2, GAB1, SRC, RASGRP4, SIPA1, PDXK, CDK6, MDM4, TOB2 |
| hsa-miR-3656 | – | RPRM | – |
| hsa-miR-3665 | RYBP, PPARD | PPP1CB, FOXO4 | OSR2, GNAI2, FGFR1, TNN |
| hsa-miR-205-3p* | RRM2B, BCLAF1, BCL2L13, TGM2 | PPM1D, RIF1, RAD21, TFDP2, CDS1, DST, PTP4A1, PAFAH1B1, FBXO5, PPP6C, APC, NCAPG2, USP16, MPP7, MAP9, SESN3, APBB2, IL8 | TOB1, PPM1D, MNT, MDM4, NOX4, NUP62, IL8, ADAM10, CIAO1, PRDX3, GKN1, FXN |
*Predicted targets of miRNAs only come from miRDB database. EGCG: Epigallocatechin-3-gallate; miRNAs: microRNAs; –: Not applicable.