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. 2017 Jan 5;130(1):93–99. doi: 10.4103/0366-6999.196586

Table 4.

KEGG pathway associating with predicted targets of miRNAs exhibiting >2-fold changes in response to both concentrations of EGCG

Pathway Count P Q
MAPK signaling pathway 52 2.25E-29 3.93E-27
Focal adhesion 37 1.44E-20 2.47E-19
Regulation of actin cytoskeleton 38 1.55E-20 2.47E-19
Insulin signaling pathway 29 2.62E-18 3.53E-17
Axon guidance 26 5.25E-16 3.83E-15
CAMs 26 1.14E-15 7.67E-15
Wnt signaling pathway 27 3.25E-15 1.84E-14
Colorectal cancer 20 3.61E-14 1.66E-13
ErbB signaling pathway 19 8.38E-13 2.99E-12
Adherens junction 18 1.54E-12 5.38E-12
Prostate cancer 18 1.08E-11 2.97E-11
Gap junction 18 2.89E-11 7.12E-11
Melanoma 16 3.19E-11 7.75E-11
Glioma 15 9.14E-11 1.97E-10
Neuroactive ligand-receptor interaction 28 1.93E-10 3.93E-10
Epithelial cell signaling in Helicobacter pylori infection 15 2.82E-10 5.54E-10
Pancreatic cancer 15 5.28E-10 1.02E-09
Endometrial cancer 13 5.60E-10 1.06E-09
Nonsmall cell lung cancer 13 9.31E-10 1.73E-09
Phosphatidylinositol signaling system 15 9.59E-10 1.77E-09
Leukocyte transendothelial migration 18 2.56E-09 4.39E-09
Calcium signaling pathway 22 3.16E-09 5.32E-09
Melanogenesis 16 1.19E-08 1.81E-08
Fc epsilon RI signaling pathway 14 1.50E-08 2.26E-08
Type II diabetes mellitus 11 1.54E-08 2.31E-08
Glycerophospholipid metabolism 13 2.27E-08 3.33E-08
B-cell receptor signaling pathway 13 6.43E-08 9.15E-08
GnRH signaling pathway 15 1.20E-07 1.65E-07
Adipocytokine signaling pathway 12 1.41E-07 1.89E-07
T-cell receptor signaling pathway 15 1.55E-07 2.02E-07

EGCG: Epigallocatechin-3-gallate; miRNAs: microRNAs; MAPK: Mitogen-activated protein kinase; CAMs: Cell adhesion molecules; KEGG: Kyoto Encyclopedia of Genes and Genomes.