Health-related quality of life among gastroesophageal reflux disease patients with or without anxiety and depression. Total SF-36 scores (A), physical component (PCS) (B) and mental component (MCS) (C) scores were much lower in subjects with anxiety, depression, and both anxiety and depression than in those without anxiety and depression for both GERD and GERD-NCCP patients, while this difference was not present in GERD-CCPpatients. bP < 0.01, subjects without anxiety and depression vs subjects with anxiety, with depression, and with both anxiety and depression. CCP: Cardiac chest pain; GERD: Gastroesophageal reflux disease; NCCP: Noncardiac chest pain.