. Author manuscript; available in PMC: 2017 Nov 1.

Published in final edited form as: Ann N Y Acad Sci. 2016 Oct 17;1383(1):97–114. doi: 10.1111/nyas.13267

Table 2.

Summary of all included growth factor–related studies

Study	Study type	Design	Number of MSCs	Outcomes
Gulotta et al.⁵⁸	In vivo rat model	Supraspinatus repair with or without allogenic BM- MSCs	10⁶ /animal	No significant difference in strength of repair, cross-sectional area, stress to failure, or stiffness. Non-significant but consistently higher amounts of fibrocartilage
Gulotta et al.⁶⁰	In vivo rat model	Supraspinatus repair with allogenic BM-MSCs either transduced with MT1-MMP or not. No non-BM-MSC controls	10⁶ /animal	Significant increases in load to failure, stiffness, and levels of fibrocartilage
Gulotta et al. ⁶¹	In vivo rat model	Supraspinatus repair with allogenic BM-MSCs either transduced with BMP-13 or not. No non- BM-MSC controls	10⁶ /animal	No significant increase in fibrocartilage, improvements in collagen organization, strength of repair, cross-sectional area, stress to failure, or stiffness
Gulotta et al. ⁶²	In vivo rat model	Supraspinatus repair with allogenic BM-MSCs either transduced with scleraxis or not. No non- BM-MSC controls	10⁶ /animal	Significant increases in fibrocartilage, load to failure, stress to failure, and stiffness
Hernigou et al.⁶³	Prospective case- controlled cohort study	All-sized RC tears repaired with or without autogenous BM-MSCs (harvested from anterior iliac spine)	51,000/ 12 mL	Significant improvement in ultrasound- and MRI-assessed healing at 6 months and 10 years. Positive correlation between concentration of BM-MSCs transferred and tendon healing at 10 years
Kida et al.⁶⁶	In vivo rat model	Supraspinatus repair with or without drilling of the greater tuberosity to release GFP BM-MSCs	n/a	Significantly higher levels of GFP BM- MSCs at repair site in drilled rats, as well as higher load to failure
Jo et al.⁶⁷	Prospective case- controlled cohort study	All-sized RC tears repaired with or without channeling of the greater tuberosity	n/a	Significantly more BM-MSCs found in channeled patients, as confirmed by flow cytometry. Significant improvement in re- tear rate but no other clinical outcomes
Taniguchi et al.⁶⁸	Prospective case- controlled cohort study	All-sized RC tears repaired with or without BMS	n/a	Significantly lower re-tear in stimulated group, especially among patients with larger tears. No testing was performed to confirm the presence of BM-MSCs.