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. 2016 Dec 30;22:5218–5227. doi: 10.12659/MSM.898623

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© Med Sci Monit, 2016

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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Involvement of ER stress and associated apoptosis signaling pathways in the cardioprotective effects of 4-PBA. (A) The expression levels of Grp78, p-PERK, PERK, CHOP, Bax, Bcl-2, p-JNK, and JNK were detected by immunoblotting assay. The normalized relative levels of Grp78 (B), p- PERK (C), CHOP (D), Caspase-12 (E), Bax (F), and p-JNK (G) were determined by densitometry. The results are represented as means ±SD from 3 independent experiments (n=3). ^# p<0.05 versus untreated control group; ^## p<0.01 versus untreated control group; ^### p<0.001 versus untreated control group; * p<0.05 versus I/R-impaired group; ** p<0.01versus I/R-impaired group; *** p<0.001 versus I/R-impaired group.