Table 1.

List of VEGF signalling‐related proteins by iTRAQ proteomic analysis from the condylar cartilage of rats fed 4 weeks of soft and hard food diet

Gene ID	Protein name	KEGG pathway	116.1/114.1	117.1/114.1
VEGFD	Vascular endothelial growth factor D precursor	rno04060:Cytokine–cytokine receptor interaction; rno04150:mTOR signalling pathway, rno04510:Focal adhesion	0.44	0.54
VGFR2	Vascular endothelial growth factor receptor 2 precursor	rno04060:Cytokine–cytokine receptor interaction; rno04144:Endocytosis	0.63	0.63
KPCB	Protein kinase C beta type	rno04010:MAPK signalling pathway; rno04012:ErbB signalling pathway; rno04020:Calcium signalling pathway	0.60	0.51
ARAF	A‐Raf proto‐oncogene serine/threonine‐protein kinase		1.78	1.66
RASN	GTPase NRas precursor	rno04010:MAPK signalling pathway; rno04012:ErbB signalling pathway	2.39	2.96
NOS3	Nitric‐oxide synthase, endothelia	rno00330:Arginine and proline metabolism; rno04020:Calcium signalling pathway	0.40	0.58
PLCG2	Phospholipase C‐gamma‐2	no00562:Inositol phosphate metabolism; rno04012:ErbB signalling pathway, rno04020:Calcium signalling	0.70	0.74
KPCT	Protein kinase C theta type	rno04270:Vascular smooth muscle contraction; rno04530:Tight junction; rno04920:Adipocytokine signalling pathway	0.61	0.64
NOS1	Nitric‐oxide synthase	rno00330:Arginine and proline metabolism; rno04020:Calcium signalling pathway	0.88	0.86
PLCG1	Phospholipase C‐gamma‐1	rno00562:Inositol phosphate metabolism; rno04012:ErbB signalling pathway; rno04020:Calcium signalling	0.87	1.01
KPCZ	Protein kinase C zeta typ	rno04144:Endocytosis; rno04530:Tight junction; rno04910:Insulin signalling pathway	0.57	0.77