Table 1.
SNPs evaluated for association with motor subtype
| PD risk SNP | Neighboring gene | Minor allele frequencies | ||
|---|---|---|---|---|
| Minor allele | UPenn PD cohort | 1000 Genomes | ||
| rs71628662 | GBA‐SYT11 | C | 0.01 | 0.02 |
| rs17649553 | MAPT | T | 0.18 | 0.24 |
| rs34311866 | TMEM175‐GAK‐DGKQ | C | 0.21 | 0.19 |
| rs12637471 | MCCC1 | A | 0.20 | 0.20 |
| rs1955337 | STK39 | T | 0.13 | 0.12 |
| rs6430538 | ACMSD‐TMEM163 | T | 0.49 | 0.50 |
| rs11724635 | BST1 | C | 0.41 | 0.44 |
| rs823118 | RAB7L1‐NUCKS | C | 0.39 | 0.47 |
| rs356182 | SNCA | G | 0.40 | 0.36 |
| rs1077989 | TMEM229B | C | 0.46 | 0.45 |
Ten single‐nucleotide polymorphisms (SNPs) previously associated with increased risk for PD were evaluated in this study. Minor allele frequencies in the UPenn discovery cohort of 251 PD patients versus minor allele frequencies for populations of European ancestry (1000genomes.org, EUR cohort) are shown.