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. 2016 Dec 5;7(1):64–73. doi: 10.1002/2211-5463.12156

Figure 5.

Figure 5

Inhibition of PDE4 and PDE5 significantly attenuates Aβ1–42‐induced cell death.(A) Noninvasive evaluation of SH‐SY5Y cell viability was undertaken using xCELLigence Real‐Time Cell Analyzer RTCA‐SP following addition of Aβ1–42 or a scrambled version of Aβ1–42 PDE 4 (rolipram) and 5 (sildenafil) inhibitors were added 6 h after Aβ1–42 addition. (B) Evaluation of changes in normalised Cell Index (n = 3) over the Aβ1–42 time‐course following inhibition of PDE9 with rolipram (left) or sildenafil (right). Errors are SEM and significances vs untreated controls determined using Student's t‐test. *P = 0.05.