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. Author manuscript; available in PMC: 2017 Jan 9.
Published in final edited form as: Brain Struct Funct. 2014 May 31;220(4):2415–2422. doi: 10.1007/s00429-014-0794-9

Fig. 3.

Fig. 3

Estradiol-mediated decreases in dendritic spine density in the nucleus accumbens core depend on mGluR5. a Estradiol decreased dendritic spine density of medium spiny neurons in the nucleus accumbens core and this decrease was blocked by pretreatment with MPEP. b Estradiol increased dendritic spine density in medium spiny neurons of the nucleus accumbens shelland mGluR5 antagonism had no effect on this action of estradiol. c Estradiol increased dendritic spine density of CA1 hippocampal pyramidal neurons and pretreatement with MPEP did not affect this increase. The number inside of each bar represents the number of animals per condition. Grey bars are significantly different than white bars p< 0.05. d-f Cumulative probability distribution plots of dendritic spine density within treatment groups for nucleus accumbens core (d), nucleus accumbens shell (e), and CA1 region of the hippocampus (f)