Table 1.
Organ | Author | Phenotype (Hyper Acute Rejection)/AR/Chronic Allograft Injury | Study Size | nHLA antibody (nHLA-Ab) | References |
---|---|---|---|---|---|
Bialic et al | chronic hemodialysis (pre-txp) | 48 | tubulin beta chain, vimentin, lamin-B1, and Rho GDP-dissociation inhibitor 2 | [23] | |
Kidney | Sutherland et al | Acute Rejection | 15 | Protein Kinase Cζ | [8] |
Li et al | Chronic Allograft Injury | 33 | Angiotensinogen (AGT) and Speedy homologue A (SPDYA) | [14] | |
Li et al | Acute Rejection | 15 | MICA | [7] | |
Li et al | Post-transplant Ab response | 18 | IgG's against 5,056 unique protein targets | [10] | |
Butte et al | ESRD | 95 | angiotensinogen and PRKRIP1 | ||
Sigdel et al | Chronic Allograft Injury | 98 | MIG (CXCL9), ITAC (CXCL11), IFN-γ, glial-derived neurotrophic factor | [13] | |
Chaudhuri et al | Acute Rejection | 124 | MICA | [36] | |
Dragun et al | Refractory vascular rejection (AR) | 33 | Angiotensin II type 1 receptor antibody | [33] | |
Dinavahi et al | Chronic Allograft Injury | 39 | peroxisomal-trans-2-enoyl-coA-reductase | [47] | |
Zou et al | Acute Rejection | 1910 | MICA | [35] | |
Narayan et al | Acute Rejection | 1 | [34] | ||
Jackson et al | Acute Rejection | 60 | anti-endothelial cell antibodies (AECAs) | [30] | |
Breimer et al | Rejection | 147 | [32] | ||
Sun et al | Acute Rejection | 226 | [49] | ||
Heart | Ismail et al | Acute Rejection | 60 | [50] | |
Fredrich et al | cardiac allograft vasculopathy (CAV) | 80 | [31] | ||
Acevedo et al | Cardiac allograft vasculopathy (CAV) | 48 | anti-hnRNP-K antibodies | [40] | |
Lung | Smith et al | Hyperacute rejection, Acute rejection | 616 | IgM Abs to nHLAs | [15] |
Otten et al | Bronchiolitis obliterans syndrome (BOS) | 11 | PSMC4, F3, LOC284058, PLUNC, ZNF33A, XP_931864 | [51] | |
Jaramillo et al | Bronchiolitis obliterans syndrome (BOS) | 27 | anti-AEC Abs | [41] | |
Goers et al | Bronchiolitis obliterans syndrome (BOS) | 36 | anti-K-alpha1 tubulin Abs | [42] | |
Tiriveedhi et al | Bronchiolitis obliterans syndrome (BOS) | N/A | anti-K-alpha1 tubulin Abs | [43] | |
Burlingham et al | Bronchiolitis obliterans syndrome (BOS) | collagen V | [44] | ||
Tirivedhi et al | Bronchiolitis obliterans syndrome (BOS) | 12 | collagen V epitopes | [45] | |
Liver | Sumitran-Holgersson et al | Rejection | 95 | Liver sinusoidal endothelial cells (LSECs) | [37] |
BMT | Wadia et al | GVHD | 190 | NuSAP1, CHAF1b | [46] |
Porcheray et al | Rejection/tolerance | 5 | PSMA4 | [52] |
N/A* in vitro cell culture