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. 2017 Jan 1;28(1):41–53. doi: 10.1091/mbc.E16-07-0557

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© 2017 Pronobis et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — Dynamics of the Chimera are similar to that of APC in APC2 + Axin complexes. (A–C) FRAP analysis of complexes formed by Axin-RFP alone, Axin-RFP coexpressed with GFP-APC2, or GFP-Chimera in SW480 cells. Ten complexes from three independent experiments. (A) Axin complexes are dynamic. Example of FRAP traces of complexes formed by Axin-RFP in SW480 cells. Unbleached (blue) and bleached cells (red). (B) Axin’s dynamics slows when APC is coexpressed. GFP-APC2 and Axin-RFP were expressed in SW480 cells. Left, recovery plateau; right, t_1/2. (C) APC2 and the Chimera have similar dynamics. The recovery plateau of the Chimera is similar to that of both Axin and APC2. However, the time needed for the Chimera to recover is more similar to that of APC2.