Table 1.
Pharmacokinetic comparisons of ibuprofen after single oral administration of Carol-F (ibuprofen arginine), Advil Liqui-Gels® (solubilized ibuprofen capsule), or Brufen (ibuprofen) at doses of 200 mg
| Parameter | Ibuprofen arginine (n=33)a | Solubilized ibuprofen capsule (n=33)a | Ibuprofen (n=33)a |
|---|---|---|---|
| Tmax (hours)b | 0.42 (0.25–1.25) | 0.5 (0.25–4) | 1.25 (0.33–4) |
| Cmax (mg/L) | 30.2±5.3 (17.5) | 29±6.6 (22.7) | 24.1±4.1 (17.2) |
| AUC0–t (mg⋅h/L) | 80.1±15.5 (19.3) | 78.5±15 (19.1) | 79.6±13.9 (17.4) |
| AUC∞ (mg⋅h/L) | 81±16.1 (19.8) | 79.4±15.5 (19.6) | 80.7±15 (18.6) |
| t½ (hours) | 2.2±0.4 (16) | 2.2±0.4 (16.8) | 2.3±0.4 (18.4) |
| Vd/F (L) | 8±1.2 (15.1) | 8.3±1.3 (15.8) | 8.2±1 (12.4) |
| Cl/F (L/h) | 2.6±0.5 (20.3) | 2.6±0.5 (17.6) | 2.6±0.4 (17.1) |
| GMR for Cmax | – | 0.952 (0.882–1.027) | 0.799 (0.741–0.862) |
| GMR for AUC0–t (90% CI)c | – | 0.982 (0.956–1.009) | 0.998 (0.971–1.025) |
Notes:
a
Values presented as arithmetic mean ± SD (CV, %);
b
median (minimum – maximum);
c
solubilized ibuprofen capsule and ibuprofen to ibuprofen arginine.
Abbreviations: Tmax, time to Cmax; Cmax, maximum concentration; AUC, area under the curve; Vd, volume of distribution; Cl, clearance; t½, half-life; GMR, geometric mean ratio; CI, confidence interval; SD, standard deviation; CV, coefficient of variation.