Table 2.
Pharmacodynamic profiles for COX2 inhibition over 8 hours after a single oral administration of Carol-F (ibuprofen arginine), Advil Liqui-Gels (solubilized ibuprofen capsule), or Brufen (ibuprofen) in healthy male subjects
| Parameter | Ibuprofen arginine (n=33)a | Solubilized ibuprofen capsule (n=33)a | Ibuprofen (n=33)a |
|---|---|---|---|
| Tmax (hours)b | 0.83 (0.33–8) | 2 (0.17–8) | 0.67 (0.33–6) |
| Imax (%) | 56.9±3.3 | 52.7±5 | 52.7±2.9 |
| WAI (%) | 18.4±2 | 18.4±2.5 | 11.6±1.2 |
| Difference for WAI (90% CI)c | – | 0 (−3.1 to 3.1) | −6 (−9.1 to −2.8) |
Notes:
a
Values presented as arithmetic mean ± SE;
b
median (minimum–maximum);
c
mean difference between solubilized ibuprofen capsule and ibuprofen arginine, and between ibuprofen and ibuprofen arginine.
Abbreviations: Tmax, time to maximum concentration; Imax, maximum inhibition; WAI, time-weighted average inhibition; CI, confidence interval; SE, standard error.