Table 2.

A few “dominant” clonotypes produce most of the circulating abs in pemphigus patients

Patient identifier	# of total clones	# of dominanta clones	% of dominant clones	% of total ab production per clone
				dominant clones	non-dominant clones
PV1a	22	3	14	19	2
PV8	37	3	8	17	1
PV16	30	6	20	9	2
PV3	34	5	15	10	2
PV3a	56	4	7	13	1
PF1	18	1	6	52	3
PF1a	23	3	13	18	2
PF4	63	7	11	7	1
PF4a	55	3	5	19	1
PF4b	52	7	13	7	1
Mean ± SEM			11 ± 1b	17 ± 4	2 ± 0c

^aDominant clones are defined as the highest producing circulating ab clonotypes that together produce more than 50% of the total abs in any patient

^bp<0.0005 compared to 50% using one-sample test of proportion

^cp=0.005 for % of total ab per clone dominant compared to non-dominant by Wilcoxon signed-rank test