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. 2017 Jan 1;28(1):141–151. doi: 10.1091/mbc.E16-08-0560

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© 2017 Villeneuve, Duran, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — Model of ST-FRB relocalization mediated by FKBP and KDELR. (A) ST-FRB-GFP localizes to the Golgi apparatus and FKBPs are located in the ER but cycle through the Golgi, being retrieved by the KDEL receptor. (B) When rapamycin is added, FKBPs passing through the Golgi bind to the FRB domain of ST-FRB-GFP and to the KDEL receptor due to their C-terminal KDEL-like sequences. (C) Retrieval of FKBP by KDEL receptor redistributes bound ST-FRB-GFP to the ER over time. (D) When rapamycin is added in the absence of KDEL receptor, ST-FRB-GFP stays in the Golgi apparatus. FKBPs are not retained in the ER and bind to the FRB domain as they pass through the Golgi.