Figure 1.

Hypermethylated and hypomethylated miRNA promoters in cholangiocarcinoma identified by overlapping genomic DMR and putative miRNA promoter coordinates. A) From 1374 putative miRNA promoter regions,¹¹ 27 and 13 overlapped with 1099 hypermethylated and 565 hypomethylated regions, respectively, common to >9/18 CC samples.⁷ B) Integrated Genomics Viewer (IGV 2.3)⁴¹ browser view on an example of a hypermethylated DMR common to 17 of 18 CC patients⁷ and overlapping with the promoter of miR-124-3 (see Supplementary Table S2). CGI: CpG island.