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. Author manuscript; available in PMC: 2017 Jan 9.
Published in final edited form as: Science. 2016 Jun 10;352(6291):1326–1329. doi: 10.1126/science.aaf6463

Figure 2. Oligodendrocyte cell states in the continuous maturation process from precursors to mature cells.

Figure 2

(A) t-SNE projection showing the trajectory from OPCs to mature oligodendrocytes. (B) Average (±s.e.m.) expression of marker genes for OPCs, COPs and VLMCs. Representative markers are overlayed on the tSNE map (gray, low expression; red, high expression). (C) smFISH for Sox10, Ctps (MFOL marker) and Klk6 (MOL marker) confirm that these populations are distinct. (D) Immunohistochemistry of COL1A1 (VLMCs), PDGFRA (OPCs and VLMCs) and Tomato LECTIN (blood vessels) in P21 brain. White arrowhead - VLMCs; yellow arrowhead- OPCs (COL1A1-). Scale bar 25μm.