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(A) Figure on the synthesis of NLS-Dox conjugate. (B) MALDI-TOF mass spectra of the synthesized NLS-Dox conjugate. (C) Schematic representation of the HMNs for co-delivery of NLS-Dox and anti-miR21 into drug-resistant cancer cells.
Abbreviations: BMPS, 3-(maleimido)-propionic acid N-hydroxysuccinimide ester; NLS, nuclear localization signal; Dox, doxorubicin; miR21, microRNA21; HDL, high-density lipoprotein.
