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. 2016 Dec 30;12:217–237. doi: 10.2147/IJN.S122171

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© 2017 Rui et al. This work is published and licensed by Dove Medical Press Limited

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Agarose gel electrophoresis analysis. (A) Gel retardation assay of complexation efficiency of anti-miR21 by NLS-Dox. Lane 1: free anti-miR21 control, lane 2–9: complexation at various N/P molar ratios. (B) Gel retardation assay of the incorporation efficiency of complexes into anionic DMPG liposomes composed, lane 1–8: encapsulation at varying DMPG:anti-miR21 weight ratios. (C) Gel retardation assay of the incorporation efficiency of complexes into anionic liposomes composed of DMPG–DOPE (1:1, m/m). (D) Gel retardation assay of the incorporation efficiency after the preparation of the HMNs followed by incubation of Apo AI with preformed DMPG–DOPE liposomes at varying DMPG:anti-miR21 weight ratios.

Abbreviations: miR21, microRNA21; DMPG, 1,2-ditetradecanoyl-sn-glycero-3-phospho-(1′-rac-glycerol); DOPE, 1,2-dioleoyl-sn glycero-3-phosphoethanolamine; HMNs, high-density lipoprotein-mimicking nanoparticles.