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Cell viability of MCF7 cells and MCF7/ADR cells was measured using a CCK-8 assay after treated with different formulations for 48 h or 96 h. MCF7 cells (A, C), MCF7/ADR cells (B, D); 48 h (A, B), 96 h (C, D). *P<0.05; ** P<0.01. Data are shown as mean ± SD (n=5).
Abbreviations: Dox, doxorubicin; miR21, microRNA21; HMNs, high-density lipoprotein-mimicking nanoparticles; NLS, nuclear localization signal.
