Figure 9.
Therapeutic efficacy evaluation of different formulations on MCF7/ADR tumor growth in nude mice. Mice with established tumors were randomized into five groups, and various formulations were administered to the tumor-bearing mice via the tail vein. (A) Primary tumor growth curves of mice receiving different preparations (n=6, mean ± SD). (B) Body weight variations of mice during the treatment (n=6, mean ± SD). *P<0.05; **P<0.01; and ***P<0.001.
Abbreviations: PBS, phosphate-buffered saline; Dox, doxorubicin; HMNs, high-density lipoprotein-mimicking nanoparticles; NLS, nuclear localization signal; miR21, microRNA21.
