Table 1.

IC₅₀ of Dox or equivalent NLS-Dox treated with various drug formulations in MCF7 and MCF7/ADR cells

Drug formulation	IC50 (μM)
	MCF7		MCF7/ADR
	48 hours	96 hours	48 hours	96 hours
Free Dox	2.43±0.22	0.61±0.17	49.39±2.58	29.96±1.46
Free NLS-Dox	6.23±0.37	1.21±0.25	16.49±1.73	4.85±0.83
HMNs (NLS-Dox + scramble inhibitor)	8.69±1.03	1.8±0.36	14.93±1.52	4.26±0.39
HMNs (NLS-Dox + anti-miR21)	6.69±0.45	0.35±0.08	6.06±0.71	1.02±0.27

Abbreviations: IC₅₀, half-maximal inhibitory concentration; Dox, doxorubicin; NLS, nuclear localization signal; HMNs, high-density lipoprotein-mimicking nanoparticles; miR21, microRNA21.