Table 2.
TNM and American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) Staging Systems for Intrahepatic Cholangiocarcinoma
| TNM stage | Criteria | ||
|---|---|---|---|
| Tx | Primary tumor cannot be assessed | ||
| T0 | No evidence of primary tumor | ||
| Tis | Carcinoma in situ (intraductal tumor) | ||
| T1 | Solitary tumor without vascular invasion | ||
| T2a | Solitary tumor with vascular invasion | ||
| T2b | Multiple tumors, with or without vascular invasion | ||
| T3 | Tumor perforating the visceral peritoneum or involving the local extrahepatic structures by direct invasion | ||
| T4 | Tumor with periductal invasion | ||
| Nx | Regional lymph nodes cannot be assessed | ||
| N0 | No regional lymph node metastases | ||
| N1 | Regional lymph node metastases present | ||
| M0 | No distant metastases | ||
| M1 | Distant metastases | ||
|
| |||
| AJCC/UICC stage | Tumor | Node | Metastasis |
|
| |||
| 0 | Tis | N0 | M0 |
| I | T1 | N0 | M0 |
| II | T2 | N0 | M0 |
| III | T3 | N0 | M0 |
| IV A | T4 | N0 | M0 |
| Any T | N1 | M0 | |
| IV B | Any T | Any N | M1 |
TNM, tumor, node, metastasis.