Table 3.
TNM stage | Criteria | ||
---|---|---|---|
Tx | Primary tumor cannot be assessed | ||
T0 | No evidence of primary tumor | ||
Tis | Carcinoma in situ | ||
T1 | Tumor confined to the bile duct, with extension up to the muscle layer of fibrous tissue | ||
T2a | Tumor invades beyond the wall of the bile duct to surrounding adipose tissue | ||
T2b | Tumors invades adjacent hepatic parenchyma | ||
T3 | Tumor invades unilateral branches of the portal vein or hepatic artery | ||
T4 | Tumor invades main portal vein or its branches bilaterally OR tumor invades the common hepatic artery OR tumor invades second-order biliary radicals bilaterally or tumor invades unilateral second-order biliary radicals with contralateral portal vein ORhepatic artery involvement | ||
Nx | Regional lymph nodes cannot be assessed | ||
N0 | No regional lymph node metastases | ||
N1 | Regional lymph node metastases (incl. nodes along the cystic duct, common bile duct, hepatic artery and portal vein) | ||
N2 | Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes | ||
M0 | No distant metastases | ||
M1 | Distant metastases | ||
| |||
AJCC/UICC stage | Tumor | Node | Metastasis |
| |||
0 | Tis | N0 | M0 |
I | T1 | N0 | M0 |
II | T2a–b | N0 | M0 |
III A | T3 | N0 | M0 |
III B | T1–3 | N1 | M0 |
IV A | T4 | N0–1 | M0 |
IV B | Any T | N2 | M0 |
Any T | Any N | M1 |
TNM, tumor, node, metastasis.