Table 2.

Pharmacokinetic Properties of Proton Pump Inhibitors

	Omeprazole	Esomeprazole	Lansoprazole	Dexlansoprazole	Pantoprazole	Rabeprazole
Bioavailability, %	30–40	64–90	80–85	-	77	52
Time to peak plasma level (tmax, hr)	0.5–3.5	1.5	1.7	1–2, 4–5	2–3	2–5
Protein binding, %	95	97	97	96	98	96.3
Half-life, hr	0.5–1	1–1.5	1.6	1–2	1–1.9	1–2
Primary excretion	Hepatic	Hepatic	Hepatic	Hepatic	Hepatic	Hepatic
Liver metabolism	CYP2C19	CYP2C19	CYP2C19	CYP2C19 CYP3A4	CYP2C19 CYP3A4	CYP2C19