FIG.2.

Partial amino acid sequence alignments of the GH-67 α-glucuronidases. The α-glucuronidases are the same as shown in Fig. 1. The alignments were generated with the PRETTY program of the GCG Wisconsin package (Accelrys Inc.), with plurality of 18 out of 20 for the consensus sequence (shown in uppercase letters). The sequences of the three subfamilies are indicated. Only the regions that are involved in the dimerization of either AguA or GlcA67A are shown, and the number of omitted residues in representative sequences of each of the subfamilies is shown. Residues involved in the dimerization of AguA or GlcA67A are highlighted in boxes, with the residue numbers of the corresponding sequence shown above them. The three catalytic residues (E285, D364, and E392 in AguA) are in bold.