FIG. 1.

Primary sequence alignment of an N-terminal region of DNA Polα catalytic subunit from various species. Included in this alignment are polymerases from protists (Toxoplasma gondii, Holosticha, Uroleptus, and Oxytricha), fungi (Saccharomyces cerevisiae and Schizosaccharomyces pombe), plants (Arabidopsis thaliana and Oryza), an insect (Drosophila), and vertebrates (Xenopus, Mus musculus, Rattus, and Homo sapiens). Residues shown in shading are a highly conserved amino acid cluster in the region; the three deleted residues in the fission yeast polαts13 allele are underlined and shaded.