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A form of Notch1 lacking both ligand-binding EGF repeats and the LNR domain, NEC-NTM, causes abnormal T-cell development. Peripheral blood was obtained from mice (n = 9 for each group) on day 54 after reconstitution with hematopoetic stem cells transduced with MigRI retroviruses encoding either NRR-NTM, which lacks only the ligand-binding domain, or NEC-NTM. Representative flow cytometric results are shown.
