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. 2004 Oct 15;114(8):1072–1081. doi: 10.1172/JCI21854

Figure 8.

Figure 8

Caspase inhibitor protects mice from I/R treatment. (A) The SAO-shocked PARP-1+/+ ileum pretreated with vehicle exhibiting destroyed mucosa and infiltration of neutrophils and leukocytes (arrows). (B) The ileum from a PARP-1+/+ mouse injected with Z-VAD-fmk prior to SAO treatment showing attenuated damages of villi and mucosa. (C) The ileum of a sham-operated animal. Pictures are representative of each group of 10 mice. (D) MPO activity in mice treated with caspase inhibitor prior to SAO shock. (E and F) PARP-1+/+ mice were subjected to renal I/R with or without a pretreatment with Z-VAD-fmk. The protective effect of the caspase inhibitor against renal dysfunction as shown by urea (F) and creatinine (E) levels in plasma after renal I/R. Note a reduced production of these markers in Z-VAD-fmk–pretreated animals. Sham: n = 6; renal I/R plus vehicle: n = 4; renal I/R plus Z-VAD-fmk: n = 6. Data in (D–F) represent the mean ± SEM for n observations.