Table 1. Table of Heterotrimers.

			gp41 sequence		Inhibitor Sensitivity#
Virus	Inhibitor	Target	Protomer A*	Protomer B&	A2B Trimer	AB2 Trimer
Ww	T20	N-HR	WT	WT	++	++
Wm	T20	N-HR	WT	L544S or V549A	++	+/-
Mw	T20	N-HR	L544S or V549A	WT	+/-	+/-
Mm	T20	N-HR	L544S or V549A	L544S or V549A	-	-
Ww	5HLAVA	C-HR	WT	WT	++	++
Wm	5HLAVA	C-HR	WT	N656D	++	+
Mw	5HLAVA	C-HR	N656D	WT	+	++
Mm	5HLAVA	C-HR	N656D	N656D	-	-

*CD4 binding protomer (cannot bind CXCR4)

^&CXCR4-binding protomer (cannot bind CD4)

^#IC50 values relative to Ww virus: “++” = within 3-fold; “+” = between 3- and 6-fold; “+/-”= between 8- and 24-fold; “-”= greater than 30-fold