Table 5.
Calculation of the G6PD deficiency (G6PDd) score. The G6PDd score is calculated on the basis of the haplotypes at the 15 WHO-classified SNPs. For each haplotype, the loss of normal G6PD function is determined according to the WHO severity class (0, I, II, III or IV) of the most severe mutation carried. See Materials and methods for more details. The G6PDd score for each individual is then the average loss of function across the two haplotypes, where males are treated as homozygous females. For example, the assigned loss of normal G6PD function for a haplotype where the most severe mutation is the class III mutation G6PD+202T is 65, so an individual with this haplotype and another with no deficiency mutations will average a G6PDd score of 32.5. Individuals were further categorized on the basis of their G6PDd score as normal G6PDd (G6PDd score = 0); Low G6PDd (0 < G6PDd score < 25, blue boxes); Medium G6PDd (25 ≤ G6PDd score < 50, yellow boxes); High G6PDd (50 ≤ G6PDd score < 85, orange boxes); or Very High (G6PDd ≥ 85, red box). Scores not observed in our study are shown in grey boxes.
|
G6PDd score |
Haplotype 1 |
||||||
|---|---|---|---|---|---|---|---|
Severity class (loss of normal G6PD function) | |||||||
0 (0) |
IV (20) |
III (65) |
II (95) |
I (100) |
|||
|
Haplotype 2 |
Severity class (Loss of normal G6PD function) |
0 (0) |
0 |
10 |
32.5 |
47.5 |
50 |
|
IV (20) |
10 |
20 |
42.5 |
57.5 |
60 |
||
|
III (65) |
32.5 |
42.5 |
65 |
80 |
82.5 |
||
|
II (95) |
47.5 |
57.5 |
80 |
95 |
97.5 |
||
|
I (100 |
50 |
60 |
82.5 |
97.7 |
100 |
||