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. Author manuscript; available in PMC: 2017 Jan 9.
Published in final edited form as: Immunity. 2016 Jul 19;45(1):74–82. doi: 10.1016/j.immuni.2016.06.024

Figure 5. B10.D2 Ly49D+Ly49A−Ly49H+ NK Cells Predominate and Preferentially Differentiate into Memory NK Cells during MCMV Infection.

Figure 5

100,000 B6 Ly49H+ NK cells were transferred into syngeneic Ly49H-deficient B6 mice on the day before infection and then infected with 2.5–5 × 103 pfu MCMV. 100,000 B10.D2 Ly49H+ NK cells were transferred into syngeneic Ly49H-deficient B10.D2 mice that had been depleted of CD8+ T cells on the day before infection and then infected with 1–2.5 × 104 pfu MCMV.

(A) The percentages of donor Ly49H+ NK cells in the blood over the course of infection are shown.

(B) The percentages of donor Ly49H+ NK cell subsets expressing Ly49D and or Ly49A in the blood over the course of infection were represented as the ratio relative to the percentages of donor Ly49H+ NK cell subsets in the blood on day 0 (pre-infection). Data are pooled from two experiments (n = 6 or 7 in each group).

(C) Ly49H+ NK cell subsets expressing Ly49D and or Ly49A in the spleen on days 0, 10, and 29 pi. Data are representative of four experiments (n = 2–4 in each experiment).

*p < 0.05, **p < 0.005 versus day 0. Error bars show SEM.