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. Author manuscript; available in PMC: 2017 Jan 9.
Published in final edited form as: Am J Respir Crit Care Med. 2005 Aug 11;172(10):1322–1330. doi: 10.1164/rccm.200412-1750OC

Figure 2.

Figure 2

Two responses to pontine carbachol elicited about 150 min apart in one experiment demonstrate long-term stability of hippocampal and cortical activations and respiratory rate slowing in response to pontine carbachol. In both records, 10 nl of carbachol was injected at the marker. Traces from the top are as follows: power of the hippocampal (Hipp) signal in the 3- to 5-Hz range, raw hippocampal recording, power of the cortical EEG in the 6- to 12-Hz range, raw cortical EEG, moving average (MA) of XII nerve activity (at this compressed time scale, the amplitude of the record represents the peak inspiratory activity in successive respiratory cycles), and the instantaneous central respiratory rate during successive 10-s intervals. The response in A was elicited before methysergide injections and the response in B was recorded about 150 min later and after methysergide injections into the XII nucleus. Note the similarity between the two responses except that the starting magnitude of XII nerve activity is different because of the methysergide actions. Two additional responses to pontine carbachol were elicited in this experiment between the two shown in A and B.